Guide Transdermal and intradermal delivery of therapeutic agents : application of physical technologies

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Commercialization of transdermal drug delivery requires technology from many disciplines beyond pharmaceutical sciences, such as polymer chemistry, adhesion sciences, mass transport, web film coating, printing, and medical technology. A comprehensive discussion of these technologies and practices, Transdermal and Intradermal Delivery of Therapeutic Agents: Application of Physical Technologies covers:Commercial development of devices and products based on transdermal physical enhancement technologiesSelecting optimal enhancement technology for a specific drug molecule using case studies Physicochemical properties and practical commercial considerations related to cost, unmet clinical needs, marketing, or intellectual property protectionTechnologies such as microneedles, iontophoresis, electroporation, and sonophoresis, with examples for delivery of small molecules, cosmeceuticals, proteins, and vaccinesPractical information on experimental procedures and challenges related to skin irritation and safety issuesUp-to-date and accessible to researchers and industry experts, this book provides a comprehensive discussion of the physical approaches and practical considerations for the laboratory and marketplace.

Therapeutic Peptides and Proteins Ajay K Banga There are more than biopharmaceuticals on the market, including more than therapeutic proteins, making biologics the fastest growing sector in the biopharmaceutical market. Bloggat om Transdermal and Intradermal Delivery of T Description Skin, once thought to be an impenetrable barrier, is an extremely active organ capable of interacting with its environment. Advancements in science combined with the need for diverse drug delivery modalities have introduced a variety of transdermal and intradermal products for existing drugs at a fraction of the cost of new drug development.

Commercialization of transdermal drug delivery requires technology from many disciplines beyond pharmaceutical sciences, such as polymer chemistry, adhesion sciences, mass transport, web film coating, printing, and medical technology.

Transdermal Drug Delivery Technologies, Companies and Markets,

A comprehensive discussion of these technologies and practices, Transdermal and Intradermal Delivery of Therapeutic Agents: Application of Physical Technologies covers: Commercial development of devices and products based on transdermal physical enhancement technologies Selecting optimal enhancement technology for a specific drug molecule using case studies Physicochemical properties and practical commercial considerations related to cost, unmet clinical needs, marketing, or intellectual property protection Technologies such as microneedles, iontophoresis, electroporation, and sonophoresis, with examples for delivery of small molecules, cosmeceuticals, proteins, and vaccines Practical information on experimental procedures and challenges related to skin irritation and safety issues Up-to-date and accessible to researchers and industry experts, this book provides a comprehensive discussion of the physical approaches and practical considerations for the laboratory and marketplace.

Product details Format Hardback pages Dimensions x x Table of contents Percutaneous Absorption and Enhancement Strategies. Microporation-Mediated Transdermal Drug Delivery. Iontophoretic Intradermal and Transdermal Drug Delivery. Skin Electroporation and Its Applications. Sonophoresis for Intradermal and Transdermal Drug Delivery. Transdermal Delivery of Peptides and Proteins. Biodegradable microneedles Biodegradable microneedles, mostly using different kinds of biodegradable polymers, including polylactic acid, chitosan, polyglycolic acid, or poly lactide- co -glycolide PLGA to form the matrix, degrade in the skin after application, whereby the release of incorporated drugs can be sustained for months by choosing the proper polymer.

Figure 3. Microneedle separation into the skin was mediated by hydrogel swelling. Figure 4. Figure 5. Microneedle-fabricating methods Fabrication of microneedles usually follows the steps of molding, preparation of microneedle matrix, casting, removal, and drying. Perspectives Microneedles effectively circumvent the skin barrier to offer this route as a potential alternative to oral and parenteral delivery of therapeutics, 44 and relatively large doses can be administered due to bulk loading of dissolvable or biodegradable systems.

Footnotes Disclosure The authors report no conflicts of interest in this work. References 1. Pain following controlled cutaneous insertion of needles with different diameters.


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Transdermal and Intradermal Delivery of Therapeutic Agents: Application of Physical Technologies

Int J Pharm. Prausnitz MR, Langer R. Transdermal drug delivery. Nat Biotechnol. In situ forming implants — an attractive formulation principle for parenteral depot formulations. Injectable and biodegradable thermosensitive hydrogels loaded with PHBHHx nanoparticles for the sustained and controlled release of insulin. Acta Biomater. An investigation into the influence of drug lipophilicity on the in vivo absorption profiles from subcutaneous microspheres and in situ forming depots.


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Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution. Development of a codrug approach for sustained drug delivery across microneedle-treated skin. J Pharm Sci. Felton LA. Transdermal and intradermal delivery of therapeutic agents application of physical technologies. Drug Dev Ind Pharm. Microneedles: an emerging transdermal drug delivery system.

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In vitro characterization of the invasiveness of polymer microneedle against skin. Effects of microneedle length, density, insertion time and multiple applications on human skin barrier function: assessments by transepidermal water loss. Toxicol In Vitro. Mechanism of fluid infusion during microneedle insertion and retraction.

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Fler böcker av Ajay K Banga

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